The incidence of hospitalization among these patients was consistent with that among patients with Covid-19 in the general population in New York City.A cohort of 36 consecutive kidney-transplant recipients had less fever, lower CD3, CD4, and CD8 cell counts, more rapid clinical deterioration, and a higher mortality than the general population of patients with Covid-19.In this report, investigators in Germany detected the spread of the novel coronavirus (2019-nCoV) from a person who had recently traveled from China to Germany for a business trip.
The Kaplan-Meier estimates of mortality by 14 days were 7.1% with remdesivir and 11.9% with placebo (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04).
Our preliminary report is intended to help inform clinicians considering the use of remdesivir.
Several steps need to be taken by manufacturers and the FDA to ensure that tests offer reliable guidance regarding the likelihood of spreading infection.SARS-CoV-2 was detected in three cats after they were cohoused with cats that had been experimentally inoculated with the virus. More than half of residents with positive test results were asymptomatic at the time of testing. ); Montefiore Medical Center–Albert Einstein College of Medicine (B.S.Z.) (Funded by Gilead Sciences; GS-US-540-5773 ClinicalTrials.gov number, The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has plunged large parts of the world into a protracted medical, social, and economic crisis.Remdesivir is a prodrug of an adenosine analogue with demonstrated antiviral activity against a broad range of RNA virus families.We enrolled hospitalized patients who were at least 12 years of age who had SARS-CoV-2 infection confirmed by polymerase-chain-reaction assay within 4 days before randomization. The change was proposed on March 22, 2020, by trial statisticians who were unaware of treatment assignments and had no knowledge of outcome data. However, there was no evidence that ACE inhibitors and ARBs affected the risk of Covid-19.The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain. Testing of a nasopharyngeal swab for SARS-CoV-2 RNA was positive. Many aspects of the Covid-19 pandemic and the public health response to it will undoubtedly contribute to widespread emotional distress and increased risk for psychiatric illness. Training, site initiation visits, and monitoring visits often were performed remotely. ), Cedars Sinai Medical Center, Los Angeles (V.T. The authors hypothesize that ACE2 may be beneficial rather than harmful during lung injury and suggest that RAAS-inhibitor withdrawal may be harmful in some high-risk patients with known or suspected Covid-19.Certain influenza strains and SARS-CoV-2 gain access to cells by means of the ACE2 receptor. ), and Evergreen Health Medical Center, Kirkland (D.L.C.) History of Medicine ), and Gilead Sciences, Foster City (A.O.) The authors vouch for the integrity and completeness of the data and the fidelity of the trial to the protocol.
I’m scared for my personal safety.Despite our inability to guarantee the accuracy of an immunity-certification process, failing to take action to identify people who could safely return to the workplace is itself an action that carries profound costs and health consequences.Diagnostic testing for SARS-CoV-2 will help in safely reopening the country, but only if tests are highly accurate.
The authors report clinical characteristics of the children and laboratory data.As in the ongoing Covid-19 pandemic, global outbreaks of infectious illnesses often develop quickly and resolve in unpredictable ways. Exclusion criteria included alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 5 times the upper limit of the normal range or estimated creatinine clearance of less than 50 ml per minute (by the Cockcroft–Gault formula). Yet our plans were being thrown out the window by a virus.The authors discuss the public health challenges faced by commercial establishments in preventing transmission of Covid-19 among their workers and customers.
The droplets decreased in number with lower-amplitude speech and were almost eliminated when the speaker’s mouth was covered with a damp cloth (shown in a video).With reference to a letter about the use of laser light scattering to visualize droplets that emanate during speech, this author describes the nature of aerosols and their potential for transmission of SARS-CoV-2.Listen to conversations with editors Eric Rubin and Lindsey Baden on the current coronavirus outbreak.The spectrum of Covid-19 presentations ranges from a mild self-limited flulike illness to life-threatening multiorgan failure.
On the fourth hospital day, respiratory distress developed; 36 hours later, the patient died. NEJM Catalyst Commentaries, Case Studies, and Conversations
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